STEVENS SEAN,MURPHY ANDREW J.,WANG LI-HSIEN,DORE JR. ANTHONY T.
申请号：
NZ62314512
公开号：
NZ623145A
申请日:
2012.10.29
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is a genetically modified mouse comprising a replacement at an endogenous mouse IL-6 locus of a mouse gene encoding IL-6 with a human gene encoding human IL-6, wherein the human gene encoding human IL-6 is under control of endogenous mouse regulatory elements at the endogenous mouse IL-6 locus. Also disclosed is a genetically modified mouse, comprising a humanisation of an endogenous mouse IL-6R&alpha； gene, wherein the humanisation comprises a replacement of mouse IL-6R&alpha； ectodomain-encoding sequence with human IL-6R&alpha； ectodomain-encoding sequence at the endogenous mouse IL-6R&alpha； locus, and wherein the humanised IL-6R&alpha； gene is under control of endogenous mouse regulatory elements.
