ONO YASUHIKO,小野 泰彦,YOSHIDA NAOYA,吉田 直哉,DAIBU KAZUHIRO,大生 和博
申请号：
JP2014001945
公开号：
JP2015048352A
申请日:
2014.01.08
申请国别(地区):
JP
年份:
2015
代理人:
摘要：
PROBLEM TO BE SOLVED: To provide a particle using a nuclear particle which is free from graininess and the like within an oral cavity when being applied to subtle granules or orally disintegrating tablets, and particularly is satisfactory in terms of hardness, disintegratability, and feeling of ingestion as an orally disintegrating tablet.SOLUTION: The cellulose nuclear particles contain cellulose and an excipient contain particles, at the ratio of 50 mass% or more, which contain 10 mass% or more of cellulose and 90 mass% or less of excipient, have an appearance bulk density of less than 0.20-0.60 g/ml, have an angle of repose of 38-48 degrees, have a tablet hardness of 50 N or more at the time of compression pressure of 3kN, pass through a sieve having sieve opening of 63 μm, and remain on a sieve having sieve opening of 20 μm.COPYRIGHT: (C)2015,JPO&INPIT【課題】本発明の目的は、核粒子を用いた粒子を細粒剤や口腔内崩壊錠に応用した場合に口腔内でざらつきなどがなく、特に口腔内崩壊錠としての硬度や崩壊性、服用感で満足いくものを提供する。【解決手段】セルロース10質量%以上と賦形剤90質量%以下とを含有し、見かけ嵩密度が0.20~0.60g/ml未満、安息角が38~48°、打圧3kN時の錠剤硬度が50N以上、目開き63μmの篩を通過し、目開き20μmの篩上に残留する粒子の割合が50質量%以上であるセルロース及び賦形剤を含有するセルロース系核粒子。【選択図】なし
