PERRY, THAO,PARKHILL, ERIC Q.,LI, XIAOFEN,KOLTUN, DMITRY,KALLA, RAO V.,ELZEIN, ELFATIH,ELBEL, KRISTYNA M.,COSMAN, JENNIFER LEIGH,CORKEY, BRITTON KENNETH,BARTLETT, MARK J.
申请号：
ARP180102392
公开号：
AR112478A1
申请日:
2018.08.22
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
Compounds with ido1 inhibitory activity for the treatment of cancer. 1. Claim 1: a formula compound (1),Each position of X1 in equation (1) is independent n, CH, or CXR； X2 is n or C, not when X2 is n； each position of x83088 in equation (1) is independent n, CH, or CR1；X°8309ES CH，CXR，o CR1；X R is hydrogen, halogen, halogen tar c833218331-83323；O lease No. c83218832626；R1 is hydrogen, deuterium, halogen, CN, ocf83233,-OchF832222，o-cf-83323；N is 0-5, if n is gt； 1, R 1 can be kept the same or different independently； R2 is hydrogen, halogen, tar c83331832626；O arilo, - CN, halide c8332183331, not replaced or replaced by one, two or three independent halogen substitutes；1. Lease No. c8332188331832626；R: cyclo-c83231；Heterocycle c833238331；O single ring or double ring arilo or heterosexual, in which case, each arilo or heterosexual of single ring or double ring arilo or heterosexual has not been replaced or replaced by one, two or three alternatives independent of halogen, - CN, halide c833226；1. Lease No. c8332188331832626；And r830808 are halogen, tar c833218331832626,Halogenated tar c83321531832626,-OCF8323,cycloquilo C833238832626；Either a heterocycle of 4-12 members, or a salt acceptable for drugs. Claim 64: a formula compound (2),X1 is independent of N, ch or CXR at each position in equation (2)； X2 is n or C, X2 is n or C, absent when X2 is n； x83088 is independent of N, ch or CR1 at each position in equation (2)；X ° 8309es ch, CXR or CR1；Xris No. c833218331-83323 or c83321833131 of hydrogen, halogen and halogen tar；R1 is hydrogen, deuterium, halogen, CN, ocf83233,-OCHF832220 O-CF-83323；N is 0-4, n is Y gt； 1, R1 can be the same or different independently；R2 is hydrogen, halogen, c83231.832626 or arilo, - CN, halide c833218331832626 and acquiro c833218331832626 which are not replaced or replaced by 1, 2 or 3 substitutes independent of halogen；R: cyclo-c83231；Heterocycle c833238331；A. single ring or double ring arilo or heteromorphic, each single ring or double
