MACLAY, TYLER,VACCA, JOSEPH,MCOMAS, CASEY CAMERON,CASTRO, ALFREDO C.
申请号：
ARP180102580
公开号：
AR112800A1
申请日:
2018.09.11
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
The application is for radon inhibitors and methods used to treat cancer, autoimmune diseases, autoimmune deficiencies or neurodegenerative diseases. Claim 1: a compound of structural formula (1)；O contains a pharmaceutically acceptable salt, wherein the thiazole ring can be replaced by - F o-Cl； CY es-c83333183277cycloquilo, c8332683318321； or a 4-10 member heterocyclic ring； a. When it is connected with the cyclic nitrogen atom of cy, x8383099 is absent； when it is connected with the cyclic carbon atom of cy, one or more halogen groups Oh, c83231 can be selected； e. X ° 8309en es nr7491u； x8310es nr7491u； R1 es c833183258e optional asphalt replaced by - Oh；e. R 3 ° c83218c833183258cpilo, - ch83228cyclo, - c832383318cyclo, - c833278cyclo, - c8332328cyclo, ring 3-7, ring 3-7, ring 3-ring 3, ring 3, ring 3, ring 3, ring 3, ring 3, ring 3, ring 3, ring 3, ring 3, ring 3, ring 3, ring 3, ring 3； a. One or more groups were selected from the halogen group to replace 3-7 members of monocyclic phenyl group or groups, which were composed of R 3 or R 3； Oh, c83321838383318383838331ajlo, halomethy, halometxi, - CN, and c833218331838383838324alcoxi； R2 es-nr749191； C (o) oc8321838383383248324lo； -7491； (c) (o) 7491； (c) 83212383318324 lessor； - 7491； (C (o) oc832283312483alquenilo；-Unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, unique, leaf, 3-7 members； unique ring-7491； single ring of C (o) n749191-3-7 members； unique ring-7491； C (o) or 5 single rings -6 members； isoaryl ring No. 7491； C (o) No. 74919 single ring, consisting of 5-6 members； among them, the aquifers c83318324archie and c83322833318324alquenilo are each selectively and independently replaced by one or more halogen groups in the R a group, No. 832323；-Or7491,-N ° 7491； - c83323833183268cyclo, fe
