The invention relates to growth hormone compounds with a long plasma half-life obtained by Fc linkage. An increased half-life is an advantage allowing a less frequent or low dosage administration of therapeutic. The invention further relates to methods of producing such compound including expression vectors for heterologous expression.本發明關於具有由Fc連接獲得之長血漿半衰期之生長激素化合物。增加之半衰期為一個優點,其允許以較低頻率或低劑量投予治療劑。本發明進一步關於產生該化合物之方法,該化合物包括用於異源表現之表現載體。