Cyclised a-conotoxin peptides

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专利权人:

The University of Queensland

发明人:

Clark, Richard,Craik, David James

申请号：

AU2006236006

公开号：

AU2006236006B2

申请日:

2006.11.15

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

#$%^&*AU2006236006B220120906.pdf#####P DPEWmmxSpwifcdgsCyd0zod alhI4,ooobn ppW. - wwd-4&-IS/I ItAO ABSTRACT This invention relates to synthetically cyplised a-conotoxin peptide having an aide cyclised backbone such that the peptide has no free N- or C- terminus, said peptide having the ability to inhibit a nicotinic acetylcholine receptor and comprising four cysteine residues bonded in pairs to form two disulfide bonds, wherein the N-terminus of the corresponding linear/non-cyclised conotoxin peptide is linked to the C-terminus by a peptide linker of such that between six and eight amino acid residues span the distance between cysteine residues I and IV.

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