FACTEUR VIII DE COAGULATION À DOUBLE MUTATION ET PROCÉDÉS ASSOCIÉS

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专利权人:

CENTRE FOR BIOSEPARATION TECHNOLOGY-VIT;CHRISTIAN MEDICAL COLLEGE

发明人:

ARUNACHALAM, VIJAYALAKSHMI MOOKAMBESWARAN,JOSEPH, BILGIMOL CHUVAPPUMKAL,KUTTY, SATHEESHKUMAR PADIKKARA,NAIR, SUKESH CHANDRAN,SRIVASTAVA, ALOK

申请号：

EP13837157

公开号：

EP2897634A4

申请日:

2013.09.12

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

A double mutant B-domain deleted Factor VIII gene having mutations at Phe309Ser and Asp519Val, respectively, is disclosed for use in the field of haemophilia therapeutics. The disclosure a double mutant B-domain deleted Factor VIII protein having mutations at Phe309Ser and Asp519Val respectively, is also disclosed, as well as methods of producing the same. The B-domain deleted Factor VIII protein having mutations at Phe309Ser and Asp519Val shows enhanced activity and stability and therefore is used in the management of haemophilia.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/