Georgia Tech Research Corporation;Emory University
发明人:
Trent H. Spencer,Christopher Doering,Philip M. Zakas,Eric Gaucher
申请号：
US15547742
公开号：
US20180009873A1
申请日:
2016.01.27
申请国别(地区):
US
年份:
2018
代理人:
摘要：
This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting.
