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BENZOTHIENYL-PYRROLOTRIAZINES DISUBSTITUEES ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE KINASE FGFR
专利权人:
BAYER PHARMA AKTIENGESELLSCHAFT;BAYER INTELLECTUAL PROPERTY GMBH
发明人:
BROHM, DIRK,HEROULT, MELANIE,COLLIN, MARIE-PIERRE,HUBSCH, WALTER,LOBELL, MARIO,LUSTIG, KLEMENS,GRUNEWALD, SYLVIA,BOMER, ULF,VOEHRINGER, VERENA
申请号:
CA2859133
公开号:
CA2859133A1
申请日:
2012.12.10
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
This invention relates to novel substituted 5-(1-benzothiophen-2-yl) pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives of formula (I) wherein R1 is hydrogen, chloro, methyl or methoxy, R2 is hydrogen or methoxy, with the proviso that at least one of R1 and R2 is other than hydrogen, G1 represents chloro, (C1-C4)-alkyl, (C1-C4)-alkoxycarbonyl, 5-membered aza-heteroaryl, or the group -CH2-OR3, -CH2-NR4R5 or -C(=0)- NR4R6, and G2 represents chloro, cyano, (C1-C4)-alkyl, or the group - CR8AR8B-OH, -CH2-NR9R10, -C(=0)-NR11R12 or -CH2-OR15, having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
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