FIELD: chemistry； pharmaceutics.SUBSTANCE: present invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of formula or stereoisomer and/or tautomer forms thereof, and/or pharmaceutically acceptable salts thereof, where R1 is H or OH； R2 is R', (C7-C8)alkyl, (C1-C6)alkylene-R', (C2-C6)alkenyl； or R2 is (C1-C6)alkyl, under the condition that in said alkyl residue, at least one hydrogen is substituted with OH or OCH3； or R2 is (C1-C6)alkylene, bonded with cycloalkylamine, where (C1-C4)alkylene forms a second bond with another carbon atom of the cycloalkylamine ring and, together with carbon atoms of the cycloalkyalmine, forms a second 5-8-member ring； R3, R5 and R8 denote H； R4 is H, (C1-C6)alkyl or (C1-C6)alkylene-R'； R6 and R6' independently denote H, (C1-C8)alkyl, (C1-C6)alkylene-R' or C(O)O-(C1-C6)alkyl； R7 is H, halogen or (C1-C6)alkyl； n equals 1； m equals 3 or 5； r equals 0 or 1 and L is O(CH2)p, where p=0； where R' is (C3-C8)cycloalkyl, (C6)aryl； where in residues R2-R8 (C6)aryl is unsubstituted or substituted with one or more suitable groups independently selected from halogen, (C1-C6)alkyl, O-(C1-C6)alkyl, where the alkyl group can be substituted with 1-3 halogen atoms. The invention also relates to use of the compound of formula (I) and a medicinal agent based on the compound of formula (I).EFFECT: obtaining novel 6-substituted isoquinoline and isoquinolinone derivatives suitable for treating and/or preventing diseases associated with Rho-kinase and/or Rho-kinase-mediated myosin light chain phosphatase phosphorylation.36 cl, 5 tblНастоящее изобретение относится к 6-замещенным производным изохинолина и изохинолинона формулы (I) или к его стереоизомерным и/или таутомерным формам, и/или к их фармацевтически приемлемым солям, где R1 представляет собой Н или ОН； R2 представляет собой R', (С7-С8)алкил, (С1-С)алкилен-R', (С2-С6)алкенил； или R2 представляет собой (С1-С6)алкил, при условии, что в указанном алкильном остатке по меньшей мере
