PROCEDE DE PREPARATION DE MONOHYDROCHLORURE DE 2-{4-[2-({[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]METHYL}SULFANYL)-3,5-DICYAN-6-(PYRROLIDIN-1-YL)PYRIDIN-4-YL]PHENOXY}ETHYL-L-ALANYL-L-ALANINATE
MAIS, FRANZ-JOSEF,HEILMANN, WERNER,OLENIK, BRITTA,KEIL, BIRGIT,BECKER, GUIDO,MEIBOM, DANIEL,KUHLMANN, THOMAS
申请号：
CA2984984
公开号：
CA2984984A1
申请日:
2016.05.02
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to a novel and improved process for the preparation of the compound 2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)-pyridin-4-yl]-phenoxy}-ethyl-L-alanyl-L-alaninate monohydrochloride of formula (I), new precursors for their preparation, as well as to the production and use of the crystalline modification I of 2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl]phenoxy}ethyl-L-alanyl-L-alaninate monohydrochloride of formula (I).
