PROCESS FOR THE PREPARATION OF 2-{4-[2-({[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]METHYL}SULFANYL)-3,5-DICYANO-6-(PYRROLIDIN-1-YL)PYRIDIN-4-YL]PHENOXY}ETHYL-L-ALANYL-L-ALANINATE MONOHYDROCHLORIDE

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专利权人:

BAYER PHARMA AKTIENGESELLSCHAFT

发明人:

MAIS, Franz-Josef,HEILMANN, Werner,OLENIK, Britta,KEIL, Birgit,BECKER, Guido,MEIBOM, Daniel,KUHLMANN, Thomas

申请号：

PH12017502010

公开号：

PH12017502010A1

申请日:

2017.11.03

申请国别(地区):

PH

年份:

2018

代理人:

摘要：

The present invention relates to a novel and improved process for the preparation of the compound 2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)-pyridin-4-yl]-phenoxy}-ethyl-L-alanyl-L-alaninate monohydrochloride of formula (I), new precursors for their preparation, as well as to the production and use of the crystalline modification I of 2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl]phenoxy}ethyl-L-alanyl-L-alaninate monohydrochloride of formula (I).

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