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NOVEL PYRIDONE DERIVATIVES, HAVING MCH ANTAGONIST ACTIVITY, AND MEDICINAL AGENT CONTAINING SAID COMPOUNDS
专利权人:
BERINGER INGEL'KHAJM INTERNATSIONAL' GMBKH;BERINGER INGELKHAJM INTERNATSIONAL GMBKH
发明人:
ShTENKAMP Dirk (DE),ШТЕНКАМП Дирк (DE),MJuLLER Shtefan Georg (DE),МЮЛЛЕР Штефан Георг (DE),LEMANN-LINTTs Torsten (DE),ЛЕМАНН-ЛИНТЦ Торстен (DE),ROT Geral'd Jurgen (DE),РОТ Геральд Юрген (DE),KLEJ Jerg,SHTENKAMP DIRK,MJULLER SHTEFAN GEORG,LEMANN-LINTTS TORSTEN,ROT GERALD JURGEN,KLEJ JERG,КЛЕЙ Йёрг (DE),RUDOL
申请号:
RU2009110446/04
公开号:
RU0002453543C2
申请日:
2007.08.20
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to compounds of general formula (I),, where groups and radicals R1, R2 independently denote H, C1-8-alkyl or C3-7-cycloalkyl, where the alkyl or cycloalkyl group can be mono- or poly-substituted with identical or different groups R11; or R2 denotes a -CH2- or -CH2-CH2- bridge which is bonded with a group Y, and R1 is as defined above, or denotes a group selected from C1-4-alkyl-CO-, C1-4-alkyl-O-CO-, (C1-4-alkyl)NH-CO- or (C1-4-alkyl)2N-CO-, where the alkyl groups can be mono- or polyfluorinated; or R1 and R2 form an alkylene bridge such that R1R2N- denotes a group selected from: azetidine, pyrrolidine, piperdine, azepan, 2,5-dihydro-1H-pyrrole, 1,2,3,6-tetrahydropyridine, 2,3,4,7-tetrahydro-1H-azepine, 2,3,6,7-tetrahydro-1H-azepine, piperazine, in which the free amino group is substituted with R13, piperidin-4-one, morpholine, thiomorpholine, 4-C1-4-alkoxy iminopiperidin-1-yl and 4-hydroxy iminopiperidin-1-yl. Wherein, when R1 and R2 form an alkylene bridge, one or more H atoms in the alkylene bridge can be substituted with identical or different groups R14, and X denotes a C1-3-alkylene bridge which can contain one, two or three identical or different C1-3-alkyl substitutes; and Y denotes a group of subformula selected from: and , where the group can be mono-substituted with a substitute R20; Z denotes -CH2-CH2- or -C(=O)-CH2-; U, V both denote CH, one of groups U, V denotes N, and the other of U, V denotes CH, where CH can be substituted with L; and L independently denotes halogen, cyano or C1-3-alkyl; and k equals 0, 1 or 2; W is selected from a group consisting of -CH2-O- and -O-CH2-; B is selected from a group consisting of phenyl, pyridyl, pyridazinyl, pyrazinyl, pyrimidinyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, tetrazolyl, furyl, thiophenyl and thiazolyl; each of which can be mono- or poly-substituted with identical or different substitutes R20; radicals R11, R13, R14, R20 assume values given in claim 1.
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