KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY;INTELLIGENT SYNTHETIC BIOLOGY CENTER
发明人:
Sun-Chang Kim,Ju Ri Shin,Ki Jung Lim,Da Jung Kim,Young Woong Lee,Su A Jang,Bong Hyun Sung
申请号：
US14846637
公开号：
US20150366992A1
申请日:
2015.09.04
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides an antimicrobial peptide polymer comprising at least one monomer which is digested by pepsin, a multimeric antimicrobial peptide complex comprising the polymer and a cell surface anchoring motif linked to the polymer, an antimicrobial microorganism displaying the multimeric antimicrobial peptide complex, an antimicrobial composition comprising the same, a method of treating an infectious disease caused by bacteria, yeast or fungi by administering the antimicrobial composition, and a method for producing the antimicrobial microorganism. According to the invention, living microorganisms displaying an antimicrobial peptide on the cell surface thereof may be administered in vivo without having to lyse the microbial cell and isolate and purify the antimicrobial peptide, so that the antimicrobial peptide exhibits antimicrobial activity. Thus, the antimicrobial peptide may be produced at significantly reduced costs so that it may have widespread use.
