TRUSTEES OF BOSTON UNIVERSITY;THE GENERAL HOSPITAL CORPORATION
发明人:
James J. Collins,Sylvain Meylan,Samuel Moskowitz
申请号：
US14914516
公开号：
US20160199328A1
申请日:
2014.08.29
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Provided herein are compositions and methods to improve treatment of chronic infections, and reduce, delay, or inhibit formation of biofilms, using specific combinations of aminoglycoside antibiotics and treatment with one or more proton motive force (PMF) stimulating compounds. These novel methods are easily adapted to clinical settings as toxicity and efficacy of the antibiotics and metabolites used have already been studied in vivo, and as dosing for both the antibiotics and metabolites are known.
