James J. Collins,Kyle R. Allison,Mark P. Brynildsen
申请号：
US15263766
公开号：
US20170119805A1
申请日:
2016.09.13
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Provided herein are compositions and methods to improve treatment of chronic infections, and reduce, delay, or inhibit formation of biofilms, using specific combinations of aminoglycoside antibiotics and high, localized concentrations of one or more PMF stimulating compounds. These novel methods are easily adapted to clinical settings as toxicity and efficacy of the antibiotics and metabolites used have already been studied in vivo, and as dosing for both the antibiotics and metabolites are known. These approaches and therapeutic methods are also useful with non-metabolic chemicals that induce proton-motive force in bacteria.
