The present disclosure describes analog conotoxin peptides of the α-conotoxin peptide RgIA. These analog conotoxin peptides block the α9α10 subtype of the nicotinic acetylcholine receptor (nAChR) and can be used for treating pain and inflammation including inflammatory pain, cancer related pain, and neuropathic pain. The RgIA analogs described in the present invention include a variety of sequence modifications and chemical modifications that are introduced to improve the drug-like characteristics of RgIA analogs and thereby increase their therapeutic value.本發明闡述α-芋螺毒素(α-conotoxin)肽RgIA之類似芋螺毒素肽。該等類似芋螺毒素肽阻斷菸鹼乙醯膽鹼受體(nAChR)之α9α10亞型且可用於治療疼痛及發炎，包括發炎性疼痛、癌症相關疼痛及神經病變疼痛。本發明中所述之RgIA類似物包括各種序列修飾及化學修飾，該等修飾經引入以改良RgIA類似物之類藥物特徵且藉此增加其治療性價值。
