芋螺毒素(CONOTOXIN)肽類似物及用於疼痛及發炎病症之治療的用途农业专利-农业学术服务平台

发明人:: MERCADO, JOSE,麦卡朵　裘斯,麥卡朵　裘斯,TARCHA, ERIC J.,泰查　艾瑞克　Ｊ,泰查　艾瑞克　Ｊ,POSAKONY, JEFFREY J.,波萨卡尼　杰佛瑞　Ｊ,波薩卡尼　傑佛瑞　Ｊ,IADONATO, SHAWN,艾多那托　夏恩,艾多那托　夏恩

摘要：: Provided herein are alpha-conotoxin peptide analogs, including alpha-conotoxin peptide analogs that are covalently attached to polyethylene glycol (PEG), and pharmaceutical compositions of such alpha-conotoxin peptide analogs. Also provided herein are methods of treating or preventing a condition conducive to treatment or prevention by inhibition of an α9-containing nicotinic acetylcholine receptor (nAChR) (e.g., the α9α10 subtype of the nAChR) in a subject.本發明提供α-芋螺毒素(conotoxin)肽類似物、包括共價連接至聚乙二醇(PEG)之α-芋螺毒素肽類似物，及此等α-芋螺毒素肽類似物之醫藥組合物。本發明亦提供治療或預防藉由抑制個體中含α9之菸鹼乙醯膽鹼受體(nAChR) (例如nAChR之α9α10亞型)有助於治療或預防之病症之方法。