The present disclosure describes analog conotoxin peptides of the α-contoxin peptide RgIA. These analog conotoxin peptides block the α9α10 subtype of the nicotinic acetylcholine receptor (nAChR) and can be used for treating pain, inflammatory conditions, inflammation, and/or cancer.本發明描述α-芋螺毒素(conotoxin)肽RgIA之芋螺毒素肽類似物。此等芋螺毒素肽類似物阻斷菸鹼型乙醯膽鹼受體(nAChR)之α9α10亞型且可用於治療疼痛、發炎病況、發炎及/或癌症。