An interferon &bgr; production promoter and a method for producing thereof are provided. The interferon &bgr; production promoter has a culture, a cell or cell components of lactic acid bacteria as an active ingredient thereof. RNA can be used for the cell component. In addition, bacteria belonging to the genus Lactobacillus, Tetragenococcus, Pediococcus or Streptococcus can be used for the lactic acid bacteria. The interferon &bgr; production promoter can be produced by culturing lactic acid bacteria and collecting a culture, a cell or cell components thereof.