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Glucocorticoid receptor agonist comprising derivatives of 2,2,4-trimethyl-6-phenyl-1,2-dihydroquinoline having a substituted oxy group
专利权人:
AYUMI Pharmaceutical Corporation
发明人:
KATO, Masatomo,TAKAI, Miwa,MATSUYAMA, Takahiro,KUROSE, Tatsuji,HAGIWARA, Yumi,MATSUDA, Mamoru,MORI, Toshiyuki,IMOTO, Kenji,DOTA, Atsuyoshi
申请号:
ES09746568
公开号:
ES2574987T3
申请日:
2009.05.12
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound represented by the formula (1) or one of its salts, for use in the prevention or treatment of a disease: wherein R1 represents the formulas (2a), (3a), (4a) or (5a); R2 represents - (CO) -R8, - (CO) O-R9, - (SO) -R10, - (SO2) -R11 or - (CO) NR12R13; R2-O- is a substituent in the 4 or 5 position of the benzene ring A; R3 represents an alkyl group having 1 to 8 carbon atoms, preferably 1 to 6 carbon atoms; R4, R5, R6 or R7 represents a halogen atom, an alkyl group having 1 to 8 carbon atoms, preferably 1 to 6 carbon atoms, which may have a substituent, an alkenyl group having 2 to 8 carbon atoms, preferably 2 to 6 carbon atoms, an alkynyl group having 2 to 8 carbon atoms, preferably 2 to 6 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, preferably of 1 to 6 carbon atoms, a nitro group or a formyl group m, n, poq represents 0.1 or 2; in the case where m, n, p or q is 2, each R4, R5, R6 or R7 can be the same or different; R8, R9, R10 or R11 represents an alkyl group having 1 to 8 carbon atoms, preferably 1 to 6 carbon atoms, which may have a substituent, an alkenyl group having 2 to 8 carbon atoms, preferably from 2 to 6 carbon atoms, a cycloalkyl group having from 3 to 10 carbon atoms, preferably from 3 to 8 carbon atoms, an aryl group that can have a substituent or a heterocyclic group that can have a substituent; R12 and R13 may be the same or different and represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, preferably 1 to 6 carbon atoms, which may have a substituent, an aryl group which may have a substituent or a heterocyclic group, wherein the disease is selected from the group consisting of an inflammatory eye disease and a dermatitis selected from the group consisting of acute eczema, subacute eczema, chronic eczema, contact dermatitis, numular eczema, self-sensitization dermatitis, Infant eczema, chronic Vidal lichen, seborrheic dermatitis, progressive palmar tyloid keratoderma, genital / anal eczema, eczema / dermatitis
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