The Regents of the University of California;Università degli Studi di Parma;Universita degli Studi di Urbino "Carlo Bo"
发明人:
PIOMELLI, Daniele,TARZIA, Giorgio,MOR, Marco,DURANTI, Andrea,TONTINI, Andrea
申请号：
ES08838096
公开号：
ES2575954T3
申请日:
2008.10.10
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound for use in the treatment of inflammation, rheumatoid arthritis, osteoarthritis, asthma, dermatitis, psoriasis, irritable bowel disease or a spinal cord injury, said compound having a structure according to Formula I ** Formula ** in which A is O or S； B is O, S or NRa； R1 and R2 are independently H, halogen, or optionally substituted alkyl of one to ten carbons； X is O, S, C (O), NRb, CHRb or zero； Y is C (O), C (S) or CHRc； Z is O, S, NRd or CHRd； V is optionally substituted alkyl of one to ten carbons or optionally substituted alkenyl of one to ten carbons, V being optionally methyl, ethyl, n-propyl, n-butyl, 1-butyl, i-butyl, 2-methylpropyl, cyclopropylmethyl, iamyl , n-amyl or hexyl in which W is aryl, heteroaryl, cycloalkyl, cycloheteroalkyl or C (R3R4R5), each of which may be optionally substituted； wherein Ra Rb: Rc and Rd are independently H, optionally substituted alkyl of one to ten carbons or thioalkyl optionally substituted of one to ten carbons； and wherein R3, R4 and R5 are independently H, optionally substituted alkyl of one to ten carbons, optionally substituted aryl, optionally substituted cycloheteroalkyl of one to ten carbons or optionally substituted heteroaryl.Un compuesto para su uso en el tratamiento de inflamación, artritis reumatoide, artrosis, asma, dermatitis, psoriasis, enfermedad del intestino irritable o una lesión de la médula espinal, teniendo dicho compuesto una estructura de acuerdo con la Fórmula I**Fórmula** en la que A es O o S； B es O, S o NRa； R1 y R2 son independientemente H, halógeno, o alquilo opcionalmente sustituido de uno a diez carbonos； X es O, S, C(O), NRb, CHRb o cero； Y es C(O), C(S) o CHRc； Z es O, S, NRd o CHRd； V es alquilo opcionalmente sustituido de uno a diez carbonos o alquenilo opcionalmente sustituido de uno a diez carbonos, siendo V opcionalmente metilo, etilo, n-propilo, n-butilo, 1-butilo, i-butilo, 2-metilpropilo, ciclopropilmetilo, iamilo, n-amilo o hexilo en la que W es arilo, heteroarilo, c
