Philip Wilson Howard;Stephen John Gregson;Zhizhi Chen
发明人:
Philip Wilson Howard,Zhizhi Chen,Stephen John Gregson
申请号：
US12610478
公开号：
US08633185B2
申请日:
2009.11.02
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Compounds of the formula I:or solvate thereof, wherein:R2 is an optionally substituted C5-20 aryl group；R6 and R9 are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR′, nitro, Me3Sn and halo；where R and R′ are independently selected from optionally substituted C1-12 alkyl, C3-20 heterocyclyl and C5-20 aryl groups；R7 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NHRR′, nitro, Me3Sn and halo；R″ is a C3-12 alkylene group, which chain may be interrupted by one or more heteroatoms and/or aromatic rings；X is selected from O, S, or NH；z is 2 or 3；M is a monovalent pharmaceutically acceptable cation；R2′, R6′, R7′, R9′, X′ and M′ are selected from the same groups as R2, R6, R7, R9, X and M respectively, or M and M′ may together represent a divalent pharmaceutically acceptable cation.
