GREGSON, STEPHEN JOHN,HOWARD, PHILIP WILSON,CHEN, ZHIZHI
申请号：
CA2604805
公开号：
CA2604805C
申请日:
2006.04.21
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Disclosed herein are compounds of the formula: (I)(see formula I)or solvate thereof, wherein: R2 is an optionally substituted C5-20 aryl group；R6 and R9are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR', nitro,Me3Snand halo； where R and R' are independently selected from optionallysubstituted C1-12alkyl, C3-20 heterocyclyl and C5-20 aryl groups； R7 is selected from H, R, OH,OR, SH, SR,NH2, NHR, NHRR', nitro, Me3Sn and halo； R" is a C3-12 alkylene group, whichchain maybe interrupted by one or more heteroatoms and/or aromatic rings； X is selectedfromO, S, or NH； z is 2 or 3； M is a monovalent pharmaceutically acceptablecation； R2', R6',R7', R9', X' and M' are selected from the same groups as R2, R6, R7, R9, X andMrespectively, or M and M' may together represent a divalent pharmaceuticallyacceptable cation. These compounds are, at least in selected embodiments,usefulfor treatment of proliferative diseases.
