CHAN, Ho Man,GU, Xiang-Ju Justin,HUANG, Ying,LI, Ling,MI, Yuan,QI, Wei,SENDZIK, Martin,SUN, Yongfeng,WANG, Long,YU, Zhengtian,ZHANG, Hailong,ZHANG, Ji Yue (jeff),ZHANG, Man,ZHANG, Qiong,ZHAO, Kehao
申请号：
PE2017001154
公开号：
PE20171307A1
申请日:
2015.12.21
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
It refers to the compound of the tripyridine derivative of formula (I), wherein - is a simple linkage or double linkage； R1 and R2 are h or halogen； R3 is halogen, phenyl, etc.； R4 is h, halogen or C1-C4 tar； R5 is Oh or C1-C4 tar； n is 0 or 1. 1. The preferred compounds are: 8 - (1,3-dimethyl-1h-pyrazol-5-il) - N - (5-fluoro-2,3-dihydrobenzofuran-4-il) methyl - [1,2,4] trinitrotoluene [4,3-c] pyridine-5-amine； N - ((5-fluoro-2,3-dihydrobenzofuran-4-il) methyl) - 8 - (2-methylpyridine-3-il) - [1] - 3] - pyr-3There are others He also mentioned a pharmaceutical composer These compounds inhibit the inhibitory complex of polybrominated diphenyl ether (PRC2) and can be used to treat lymphoma, tumor and cancer.SE REFIERE A COMPUESTOS DERIVADOS DE TRIAZOLOPIRIMIDINA DE FORMULA (I) DONDE ----- ES UN ENLACE SIMPLE O UN ENLACE DOBLE； R1 Y R2 SON H O HALOGENO； R3 ES HALOGENO, FENILO, ENTRE OTROS； R4 ES H, HALOGENO O ALQUILO C1-C4； R5 ES OH O ALQUILO C1-C4； n ES 0 O 1. SON COMPUESTOS PREFERIDOS: 8-(1,3-DIMETIL-1H-PIRAZOL-5-IL)-N-((5-FLUORO-2,3-DIHIDROBENZOFURAN-4-IL)METIL)-[1,2,4]TRIAZOLO[4,3-c]PIRIMIDIN-5-AMINA； N-((5-FLUORO-2,3-DIHIDROBENZOFURAN-4-IL)METIL)-8-(2-METILPIRIDIN-3-IL)-[1,2,4]TRIAZOLO[4,3-c]PIRIMIDIN-5-AMINA； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DEL COMPLEJO REPRESIVO DEL POLINOMIO 2 (PRC2) SIENDO UTILES EN EL TRATAMIENTO DE LINFOMAS, TUMORES Y CANCER
