DUNJA UROSEV,LEONARD G. PRESTA,MARIO SANCHES,STACEY A.L. TOM-YEW
申请号：
BR112018007152
公开号：
BR112018007152A2
申请日:
2016.10.07
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
There is provided herein the polyspecific antigen-binding polypeptides construct for including at least two different heterodimers, each heterodimer includes heavy chain and light chain.At least one heterodimer includes the areas Fab containing lambda light chain and at least one heterodimer includes the areas Fab containing κ light chains.It includes to promote the correct pairing between the heavy chain and light chain to form the amino acid modification of required polyspecific antigen-binding polypeptides construct to form one or more of heavy chain immunoglobulin and light chain of the antigen-binding polypeptides construct.The amino acid modification can be located at CH1And/or CLStructural domain, VHAnd/or VLIn structural domain or combinations thereof.
