Binyam Bezabeh;Mehdi Mesri;Francine Chen;Michael Jeffers;Peter Mezes;Nikolia Khramtsov;Gregory M. Landes;Ian Foltz;Kam Fai Tse;Gary Starling
发明人:
Gregory M. Landes,Francine Chen,Binyam Bezabeh,Ian Foltz,Kam Fai Tse,Michael Jeffers,Mehdi Mesri,Gary Starling,Peter Mezes,Nikolia Khramtsov
申请号：
US13305898
公开号：
US20120251555A1
申请日:
2011.11.29
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
