#$%^&*AU2013242840A120131031.pdf#####ABSTRACT The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to continguous heavy and light chain sequences spanning the framework regions (FRs) and/or complementarity determining regions (CDRs), specifically from FRI through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.1/29 Figure 1 ELISA assay of anti-TIM- I mAbs 1.29,2.56.2,2.59.2, and 2.45.1 against the TIM-i antigen 1.6 1.4 1.2 0.2 0o Treatments
