Apparatus and methods are described for substantially immobilizing a breast for use in medical imaging. In an exemplary embodiment, an apparatus for substantially immobilizing a breast is provided, including a first support member connected to a first and second base, the bases capable of engagement with the torso of a patient, the first support member defining an inner area substantially covered by a first membrane. A corresponding second support member, defining a second inner area substantially covered by a second membrane, is engageable to the first support member such that the inner areas are substantially aligned to substantially immobilize a breast, the membranes defining a pocket to receive a breast.