Tomas Hudlicky,Lukas Werner,Ales Machara,Martina Wernerova,Mary Ann Endoma-Arias
申请号：
US14591382
公开号：
US09045497B1
申请日:
2015.01.07
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A high-yielding method for the N-demethylation of oxycodone- and oxymorphone-N-oxides by the reaction of these compounds with cyclodehydration reagents has been performed. This method has been utilized to improve the synthesis of various morphine analogs, such as naltrexone, nalbuphone and naloxone.
