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Processes and intermediates in the preparation of morphine analogs via N-demethylation of N-oxides using cyclodehydration reagents
专利权人:
Tomas Hudlicky
发明人:
Tomas Hudlicky,Lukas Werner,Ales Machara,Martina Wernerova,Mary Ann Endoma-Arias
申请号:
US13462059
公开号:
US08957072B2
申请日:
2012.05.02
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A high-yielding method for the N-demethylation of oxycodone- and oxymorphone-N-oxides by the reaction of these compounds with cyclodehydration reagents has been performed. This method has been utilized to improve the synthesis of various morphine analogs, such as naltrexone, nalbuphone and naloxone.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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