Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer

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专利权人:

发明人:

Tomas Hudlicky,Ales Machara

申请号：

US14571714

公开号：

US09108967B2

申请日:

2014.12.16

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The present application is directed to an efficient conversion of C-14 hydroxylated morphine alkaloids to various morphine analogs, such as naltrexone, naloxone and nalbuphone. One feature of this process is an intramolecular functional group transfer from the C-14 hydroxyl to the N-17 nitrogen atom following a palladium-catalyzed N-demethylation.

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