Process for preparation of 1,2-diamino-cyclohexane-platinum(II) complexes

• 收藏
• 分享

专利权人:

发明人:

申请号：

EP09008348.6

公开号：

EP2208731B1

申请日:

2009.06.26

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

The present invention is directed to a manufacturing process for 1,2-diamino-cyclohexane-platinum(II) complexes, specifically to a manufacturing process for oxaliplatin.The process is straightforward, economical and applicable to industrial production. It comprises the reaction of (DACH)PtCl2 with silver sulfate (Ag2SO4) and the subsequent reaction of the resulting Pt sulfate complex (DACH)Pt(aq)2SO4 with barium oxalate (BaC2O4) or an equimolar mixture of barium hydroxide and oxalic acid to yield oxaliplatin in high purity with a low silver and low nitrate content.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/