The National Institute for Biotechnology in the Negev Ltd.
发明人:
PORGADOR, Angel,GAZIT, Roi
申请号：
AU2019221324
公开号：
AU2019221324A1
申请日:
2019.02.14
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
A Tumor Micro-Environment (TME) responsive expression vector including a nucleic acid sequence encoding a synthetic promoter comprising one or more promoter- response-elements, and a nucleic acid sequence encoding immune-effector genes, such as chimeric antigen receptor. The TME responsive vector is designed to induce the expression of immune-effector genes within TME, and not in normal healthy tissues, thus focusing immune activities, increasing safety and reducing the ON-target OFF- tumor hazard.
