THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD.
发明人:
PORGADOR, ANGEL,GAZIT, ROI
申请号:
CA3093628
公开号:
CA3093628A1
申请日:
2019.02.14
申请国别(地区):
CA
年份:
2019
代理人:
摘要:
A Tumor Micro-Environment (TME) responsive expression vector including a nucleic acid sequence encoding a synthetic promoter comprising one or more promoter- response-elements, and a nucleic acid sequence encoding immune-effector genes, such as chimeric antigen receptor. The TME responsive vector is designed to induce the expression of immune-effector genes within TME, and not in normal healthy tissues, thus focusing immune activities, increasing safety and reducing the ON-target OFF- tumor hazard.