Общество с ограниченной ответственностью "ИВА" (RU)
发明人:
Свердлов Евгений Давидович (RU),Алексеенко Ирина Васильевна (RU),Виноградова Татьяна Викторовна (RU),Копанцев Евгений Павлович (RU),Коробко Игорь Викторович (RU),Костина Мария Борисовна (RU),Монастырс
申请号：
RU2013114741/10
公开号：
RU2013114741A
申请日:
2013.04.02
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. tumor specific promoter, consisting of: A) nucleotide sequence of SEQ ID NO: 2 or its functional derivative and b) a nucleotide sequence selected from the group consisting of: (i) the nucleotide sequence of SEQ ID NO: 1 or a functional derivative thereof and (ii) the nucleotide sequence of SEQ ID NO: 3 or a functional proizvodnogo.2. The promoter according to claim 1, wherein the sequence SEQ ID NO: 2 is located upstream (5 direction) relative to the sequence SEQ ID NO: 1 or SEQ ID NO: 3.3. The promoter according to claim 1, wherein the sequence SEQ ID NO: 2 is located below (in 3-direction) relative to the sequence SEQ ID NO: 1 or SEQ ID NO: 3.4. The promoter according to any one of the preceding claims, which further comprises a linker sequence between the sequence according to subparagraph A) and the sequence according to subparagraph B) .5. The promoter of claim 2 having the sequence given in SEQ ID NO: 4 or SEQ ID NO: 5.6. The promoter of claim 3 having the sequence given in SEQ ID NO: 6 or SEQ ID NO: 7.7. The expression cassette comprising in the 5 to 3 a promoter according to any one of claims 1-6, encoding sequence operably linked to a promoter and a polyadenylation signal, wherein expression of the coding sequence is under the control of said promoter, the functionality of the expression cassette is the expression contained therein encoding posledovatelnosti.8. The expression cassette according to claim 7, wherein the coding sequence codes for therapeutic proteins or peptides, antigens, antisense RNA or ribozimy.9. The expression cassette according to claim 8, wherein the encoding Sequence1. Опухолеспецифичный промотор, состоящий из:А) нуклеотидной последовательности SEQ ID NO: 2 или ее функционального производного иБ) нуклеотидной последовательности, выбранной из группы, состоящей из:(i) нуклеотидной последовательности SEQ ID NO: 1 или ее функционального производного и(ii) нуклеотидной последовательности SEQ ID NO:3 или ее функционального производного.2
