WANG YAOHE,JIANG GUOZHONG,WANG PENGJU,GAO DONGLING,LEMOINE NICK
申请号：
IN7697/CHENP/2013
公开号：
IN2013CN07697A
申请日:
2013.09.23
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
Provided is an oncolytic adenovirus Ad TD hIL12 for target therapy of human tumor which is deposited in China Center for Type Culture Collection with an accession number CCTCC NO: V201031. The viral vector is C subclass type 5 adenovirus Ads which has three genes E1A CR2 E1B19K and E3gp 19K deleted and expresses p35 and p40 subgroup gene sequences of human IL12 under the control of the E3gp 19K promoter. Oncolytic cells are replicated in tumor cells by infecting the tumor cells with the viruses and at the same time hIL12 having a variety of anti tumor effects is produced in the tumor tissue at a high level. hIL12 has the effect of anti tumor angiogenesis can regulate the body s immunity to make the body produce specific anti tumor immunity kill distant metastatic tumor cells and prevent tumor recurrence. The viral vector of the present invention can be used as a targeting genetic engineering drug for treating various solid tumors not only can be used for intratumoral injection can also be used for intraperitoneal and intrathoracic injection without causing significant side effects thus having better efficacy and safety.
