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DERIVADO DE AMINOPIRAZOL
专利权人:
CHUGAI SEIYAKU KABUSHIKI KAISHA
发明人:
TAKA, NAOKI,MATSUSHITA, MASAYUKI,HAYASE, TADAKATSU,HYODO, IKUMI,KOCHI, MASAMI,NISHII, HIROKI,NAKANISHI, YOSHITO,MIO, TOSHIYUKI,WANG, LISHA,ZHAO, WEILI,OHMORI, MASAYUKI,TAKAMI, KYOKO,EBIIKE, HIROSATO
申请号:
PE0001812012
公开号:
PE07952012A1
申请日:
2010.08.05
申请国别(地区):
PE
年份:
2012
代理人:
摘要:
Aminopirazol refers to compounds of formula (i) wherein R1 is H, halogen, alkyl Hydroxy, CN, (C1 - C6), among others R2 is H, halogen, Nitro, haloalquilo (c1-c4), among others R3 is H, alkyl (aryl (C1 - C5) C6 C10) alkyl (C1 - C6) or haloalquilo (c1-c4) R4 is H, halogen, alkyl (C1 - C3) CN, among others it is from 5 to 10 members or heteroaryl aryl (C6 C10).Preferred compounds are: [5 - (2 - amino - 1 - methyl - 5 - 1H benzimidazole - yl) - 1h-pyrazol-4-yl] - 1H indole - 3 - il) methanone 5 - amino - [1 - (2 - methyl - 5 - 1H benzimidazole il) - 1h-pyrazol-4-yl] - (6) - pyrrolidin-3-yl - 1 - methyl - 2 - 1H indole - il) methanone 5 - amino - [1 - (2 - methyl - 5 - 1H benzimidazole - yl) - 1h-pyrazol-4-yl] - [6 (- 4 - hydroxy - Piperi DIN - 1 - methyl) - 1H indole - 3 - yl] - methanone among others.It also relates to a Pharmaceutical composition. These compounds are inhibitors of the kinase Family of Fibroblast Growth Factor receptor (FGFR) being useful in the treatment of cancerSE REFIERE A COMPUESTOS DERIVADOS DE AMINOPIRAZOL DE FORMULA (I) DONDE R1 ES H, HIDROXI, HALOGENO, CN, ALQUILO(C1-C6), ENTRE OTROS R2 ES H, HALOGENO, NITRO, HALOALQUILO(C1-C4), ENTRE OTROS R3 ES H, ALQUILO(C1-C5), ARIL(C6-C10)-ALQUILO(C1-C6) O HALOALQUILO(C1-C4) R4 ES H, HALOGENO, ALQUILO(C1-C3), CN, ENTRE OTROS A ES HETEROARILO DE 5 A 10 MIEMBROS O ARILO(C6-C10). SON COMPUESTOS PREFERIDOS: [5-AMINO-1-(2-METIL-1H-BENCIMIDAZOL-5-IL)-1H-PIRAZOL-4-IL]-(1H-INDOL-2-IL)-METANONA [5-AMINO-1-(2-METIL-1H-BENCIMIDAZOL-5-IL)-1H-PIRAZOL-4-IL]-(6-PIRROLIDIN-1-ILMETIL-1H-INDOL-2-IL)-METANONA [5-AMINO-1-(2-METIL-1H-BENCIMIDAZOL-5-IL)-1H-PIRAZOL-4-IL]-[6-(4-HIDROXI-PIPERIDIN-1-ILMETIL)-1H-INDOL-2-IL]-METANONA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA QUINASA DE LA FAMILIA DEL RECEPTOR DEL FACTOR DE CRECIMIENTO FIBROBLASTICO (FGFR) SIENDO UTILES EN EL TRATAMIENTO DE CANCER
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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