ARTIFICIAL DNA-BINDING PROTEINS AND USES THEREOF

• 收藏
• 分享

专利权人:

发明人:

申请号：

EP14802414.4

公开号：

EP3071592A2

申请日:

2014.11.20

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

The present invention relates to proteins consisting of an artificial DNA-binding domain (DBD) and related molecules and uses thereof. In particular, the proteins are ZF-DBD or TALE-DBD and are used for the treatment of eye disorders caused by gain of function mutation. The disorder may be ADRP, in particular ADRP caused by mutation in the rhodopsin gene. The present invention also relates to a method to identify cis-regulatory elements and to modulate them via DBDs.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/