以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法农业专利-农业学术服务平台

发明人:: FETELL, MICHAEL,费泰尔　麦可,費泰爾　麥可,MALAMUT, RICHARD,曼拉默特　理查,LAMSON, MICHAEL J.,兰森　麦可Ｊ,蘭森　麥可Ｊ,SPIEGELSTEIN, OFER,史皮吉史堤恩　奥佛,史皮吉史堤恩　奧佛,GOLDBERG, YIGAL PAUL,葛柏格　伊葛　保罗,葛柏格　伊葛　保羅,PRICE, NICOLA ANNE,布莱斯　尼,费泰尔麦可,費泰爾麥可,曼拉默特理查,兰森麦可J,蘭森麥可J,史皮吉史堤恩奥佛,史皮吉史堤恩奧佛,葛柏格伊葛保罗,葛柏格伊葛保羅,布莱斯尼

摘要：: Methods of treating postherpetic neuralgia in a mammal with a pharmaceutical composition comprising a spiro-oxindole compound of the formula: are disclosed. The methods provide excellent penetration of the spiro-oxindole compound into the affected skin area to effectively reduce the severity of the postherpetic neuralgia and/or to alleviate the postherpetic neuralgia with minimal or negligible systemic exposure of the spiro-oxindole compound.本發明揭示以包含下式之螺吲哚酮化合物之醫藥組合物治療哺乳動物之帶狀疱疹後遺神經痛的方法：該等方法以該螺吲哚酮化合物之最小或可忽略之全身曝露量提供該螺吲哚酮化合物極佳地滲透進入患部皮膚區域中，以有效地降低帶狀疱疹後遺神經痛之嚴重度及/或緩解帶狀疱疹後遺神經痛。