Wu, Herren,Damschroder, Melissa,Dall'Acqua, William,DallAcqua, William
申请号：
AU2010227001
公开号：
AU2010227001B2
申请日:
2010.10.06
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2010227001B220120607.pdf#####ABSTRACT The present invention relates to methods of reengineering or reshaping antibodies to reduce 5 the immunogenicity of the antibodies, while maintaining the immunospecificity of the antibodies for an antigen. In particular, the present invention provides methods of producing antibodies immunospecific for an antigen by synthesizing a combinatorial library comprising complementarity determining regions (CDRs) from a donor antibody fused in frame to framework regions from a sub-bank of framework regions. The present invention 10 also provides antibodies produced by the methods of this invention.
