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DERIVATIVES OF COLLAGEN-BINDING HAIRPIN PEPTIDES
专利权人:
发明人:
申请号:
EP13846400.3
公开号:
EP2909226A1
申请日:
2013.10.18
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
Compounds of interest, for example active pharmaceutical ingredients, probes or inactive carriers, may be delivered to a site of interest by conjugating the compound of interest to a collagen-binding linear hairpin (CBLH) peptide to form a molecule of Formula (I) and then providing the molecule to the site of interest where the CBLH peptide binds to collagen at the site of interest thereby delivering the compound of interest to the site of interest. Molecule of Formula (I) are: (I) where: Y is a first compound of interest Z is a second compound of interest n and m are independently 0 or 1 with the proviso that at least one of n and m is 1 and, CBLH is a collagen-binding linear hairpin peptide having 19 or fewer amino acids and having a turn amino acid sequence comprising 4 to 6 amino acid residues providing a stable turn structure, the turn sequence flanked on one side by a first flanking sequence having a WT(W/Y) motif and flanked on the other side by a RR second flanking sequence having a WT(W/R) motif, the W residue at position 1 of the first flanking sequence forming a cross-strand indole-indole or cation-&pgr interaction pair with the amino acid residue at position 3 of the second flanking sequence without any disulfide bond.
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