DONG-YEOP SHIN,HYUN-KYU KIM,JAE-CHUN RYU,YONG-KYUN PARK
申请号：
BR112018006850
公开号：
BR112018006850A2
申请日:
2016.11.24
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The present invention provides a process for purifying (2r, 3r, 4s) -6-amino-4- [n- (4-chlorophenyl) -N- (1h-imidazol-2-ylmethyl) amino] -3-hydroxy 2-methyl-2-dimethoxymethyl-3,4-dihydro-2h-1-benzopyran comprising the conversion of one (2r, 3r, 4s) -6-amino-4- [n- (4-chlorophenyl) -n - (1h -imidazol-2-ylmethyl) amino] -3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2h-1-benzopyran in a crystalline form thereof. and further, the present invention provides a novel crystalline form of (2r, 3r, 4s) -6-amino-4- [n- (4-chlorophenyl) -n- (1h-imidazol-2-ylmethyl) amino] -3 -hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2h-1-benzopyran and processes for its preparation.a presente invenção fornece um processo para purificação de (2r,3r,4s)-6-amino-4-[n-(4-clorofenil)-n-(1h-imidazol-2-ilmetil)amino]-3-hidróxi-2-metil-2-dimetoximetil-3,4-dihidro-2h-1-benzopirano, que compreende a conversão de um (2r,3r,4s)-6-amino-4-[n-(4-clorofenil)-n-(1h-imidazol-2-ilmetil)amino]-3-hidróxi-2-metil-2-dimetoximetil-3,4-dihidro-2h-1-benzopirano amorfo em uma forma cristalina do mesmo. e ainda, a presente invenção fornece uma nova forma cristalina de (2r,3r,4s)-6-amino-4-[n-(4-clorofenil)-n-(1h-imidazol-2-ilmetil)amino]-3-hidróxi-2-metil-2-dimetoximetil-3,4-dihidro-2h-1-benzopirano e processos para preparação da mesma.
