METHOD FOR PURIFYING BENZOPYRAN DERIVATIVE, CRYSTAL FORM THEREOF, AND METHOD FOR PREPARING CRYSTAL FORM

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专利权人:

LTD.;HANLIM PHARMACEUTICAL CO.

发明人:

RYU, JAE-CHUN,PARK, YONG-KYUN,KIM, HYUN-KYU,SHIN, DONG-YEOP

申请号：

CA3001547

公开号：

CA3001547A1

申请日:

2016.11.24

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The present invention provides a method for purifying (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran, comprising converting amorphous (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran into a crystal form thereof. In addition, the present invention provides: a novel crystal form of the (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran； and a preparation method therefor.

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