PROBLEM TO BE SOLVED: To provide a method for obtaining a chrystal form E minodronic acid hydrate (CAS Number: 155648-60-5) represented by formula (I).SOLUTION: In the method which is applicable to the industrial production of various scales, the friction between particles that can convert a crystal form D or a mixture thereof with a crystal form E to the crystal form E, is utilized. The method that causes frictional pressure-welding between particles by various means which are applicable in industrial scale such as sieving, atomization, pulverization by shaking, cyclone-type crushing, conical mill type grounding, and suspension milling or the like, is especially advantageous from the stand point of industrial production, yield, and reproducibility.SELECTED DRAWING: Figure 14COPYRIGHT: (C)2016,JPO&INPIT【課題】式(I)で表される結晶型Eのミノドロン酸水和物(CAS番号:155648-60-5)を取得する方法の提供。【解決手段】種々のスケールの工業的生産に応用可能な、当該方法では、結晶型Dまたは結晶型Eとの混合物を、結晶型Eへの変換可能な、粒子相互の摩擦を使用する方法。篩分け、微粒子化、振盪粒子化、サイクロン型破砕化、コニカルミル型粉砕化、並びに、縣濁磨砕等の、工業的スケールに応用可能な様々な手法によって、粒子相互の摩擦圧接を引き起こす方法は、工業的生産、収率、ならびに、再現性の観点から、特に有利である。【選択図】図14
