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Eye drops in form of solution comprising benzopyran derivative or pharmaceutically acceptable salt thereof
专利权人:
Ltd.;Hanlim Pharmaceutical Co.
发明人:
SHIN, Dong-Yeop,KIM, Hu-Seong,LEE, Geun-Hyeog,KIM, Kyung-Joon,CHO, Yun-Seok,O, Mi-Jin,KIM, Mi-Jung
申请号:
AU2019226830
公开号:
AU2019226830A1
申请日:
2019.02.18
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
The present invention provides eye drops in the form of a solution comprising: in an aqueous medium, (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazole-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran or a pharmaceutically acceptable salt thereof; propylene glycol as a stabilizer; and a pH adjusting agent, wherein the eye drops have a pH of 4.0 to 5.0. The eye drops of the present invention can contain (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazole-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran or a pharmaceutically acceptable salt thereof at a high concentration, and also the eye drops have excellent stability. In addition, the medicament for preventing or treating macular degeneration, according to the present invention, can be stored for a long period of time.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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