INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS

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专利权人:

SANOFI

发明人:

CHOI-SLEDESKI, YONG MI,LIANG, GUYAN,NIEDUZAK, THADDEUS R.,POLI, GREGORY B.,SHUM, PATRICK WAI-KWOK,STOKLOSA, GREGORY T.,ZHAO, ZHICHENG

申请号：

SG2012040994

公开号：

SG181504A1

申请日:

2010.12.21

申请国别(地区):

SG

年份:

2012

代理人:

摘要：

The present invention discloses and claims a series of substituted indolyl-piperidinyl benzylamines of formula (I), wherein R1, R2 and R3 are as described herein. More specifically, the compounds of this invention are inhibitors of β-tryptase and are, therefore, useful as pharmaceutical agents. Additionally, this invention also discloses methods of preparation of substituted indolyl-piperidinyl benzylamines. In one of the embodiments, there is provided the compounds of formula (I) wherein R3 is (II).

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