Patrick Wai-Kwok SHUM;Yong Mi CHOI-SLEDESKI;Gregory T. STOKLOSA;Guyan LIANG;Thaddeus R. NIEDUZAK;Gregory B. POLI;Zhicheng ZHAO
发明人:
Yong Mi CHOI-SLEDESKI,Guyan LIANG,Thaddeus R. NIEDUZAK,Gregory B. POLI,Patrick Wai-Kwok SHUM,Gregory T. STOKLOSA,Zhicheng ZHAO
申请号：
US13488539
公开号：
US20120245161A1
申请日:
2012.06.05
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention discloses and claims a series of substituted indolyl-piperidinyl benzylamines of the formulawherein R1, R2, R4 and R5 are as described herein. More specifically, the compounds of this invention are inhibitors of β-tryptase and are, therefore, useful as pharmaceutical agents. Additionally, this invention also discloses methods of preparation of substituted indolyl-piperidinyl benzylamines.
