COMPOSITIONS AND METHODS OF TREATING T CELL MEDIATED DISORDER

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专利权人:

M. Edward Medof

发明人:

M. Edward Medof,Feng Lin,Michael G. Strainic

申请号：

US13505976

公开号：

US20120219566A1

申请日:

2010.11.04

申请国别(地区):

US

年份:

2012

代理人:

摘要：

A method of generating a CD4+FoxP3+ Treg cell, the method includes administering at least one complement antagonist to a naive CD4+ T cell at an amount effective to substantially inhibits C3a receptor (C3aR) and/or C5a receptor (C5aR) signal transduction in the CD4+ T cell, induce TGF-β1 expression of the CD4+ T cell, and induce differentiation of the of the naive CD4+ T cell into a CD4+FoxP3+ Treg cell.

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