USE OF OXYGENATED CHOLESTEROL SULFATES (OCS) FOR TREATING ACUTE LIVER FAILURE

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专利权人:

VIRGINIA COMMONWEALTH UNIVERSITY;THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS;DURECT CORPORATION

发明人:

REN,SHUNLIN,THEEUWES,FELIX,BROWN,JAMES,E.,LIN,WEIQI

申请号：

RSP20220182

公开号：

RS63002B1

申请日:

2014.12.23

申请国别(地区):

RS

年份:

2022

代理人:

摘要：

Methods of preventing and/or treating ischemia, organ dysfunction and/or organ failure, including multiple organ dysfunction syndrome (MODS), and necrosis and apoptosis associated with organ dysfunction/failure, are provided. For instance, the methods involve contacting organ(s) with an oxygenated cholesterol sulfate (OCS), e.g. 5-cholesten-3,25-diol, 3-sulfate (25HC3S). The organ(s) may be in vivo (e.g. in a patient that is treated with the OCS) or ex vivo (e.g. an organ that has been harvested from a donor and is to be transplanted).

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